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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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通过目标功能连接的受体丰富分析 (REACT) 成功扩展到ASL成像,匹配BOLD fMRI揭示分子通路. ASL和BOLD fMRI为大脑功能提供了互补的见解.

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科学领域:

  • 神经成像是一种神经成像.
  • 分子神经科学 分子神经科学
  • 功能神经解剖学 功能神经解剖学

背景情况:

  • 目标功能连接的受体丰富分析 (REACT) 将分子数据与功能磁共振成像 (fMRI) 集成在一起.
  • 之前的REACT应用仅限于血液氧气水平依赖 (BOLD) 的fMRI.
  • 动脉脊柱标记 (ASL) fMRI提供了更直接的神经元活动测量方法,适合药理学研究.

研究的目的:

  • 将REACT战略扩展到ASL的fMRI.
  • 为了比较ASL衍生的和BOLD衍生的分子丰富功能连接 (FC) 地图.
  • 评估ASL和BOLD FC的空间相似性和测试-重新测试可重复性.

主要方法:

  • 同时获得的ASL/BOLD静止状态fMRI数据来自29名健康受试者.
  • 为了估计6个分子系统的ASL和BOLD FC地图,应用了REACT.
  • 我们比较了ASL和BOLD FC地图的空间相似性和测试重复测试可重复性.

主要成果:

  • 在ASL和BOLD模式中观察到分子丰富的FC的强大的空间模式.
  • 在ASL和BOLD FC地图之间发现了适度的空间相似性.
  • 对于大多数分子网络来说,ASL和BOLD FC之间的测试-重新测试可重复性是可比的.

结论:

  • 对于检测与特定分子路径相关的功能电路,ASL fMRI 和 BOLD fMRI 同样具有信息性.
  • ASL和BOLD fMRI可能会提供关于分子丰富功能电路的补充信息.
  • 将REACT扩展到ASL成像扩大了其在神经科学研究中的适用性.