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Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
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主要范式之外的PD-1受体:瘤内在作用和对检查点封锁的临床影响
C Donini1, F Galvagno1, R Rotolo1
1Department of Oncology, University of Turin, Turin, Italy.
British journal of cancer
|July 20, 2023
概括
癌症免疫疗法利用检查点抑制剂 (CI) 抗体阻止T细胞上的PD-1. 新兴研究显示PD-1也在癌细胞内发挥作用,其作用仍在被澄清.
科学领域:
- 免疫学和瘤学
- 癌症生物学 癌症生物学
- 分子信号传输的方法
背景情况:
- 免疫检查点抑制剂 (CI) 抗体针对T淋巴细胞上的编程细胞死亡蛋白1 (PD-1) 是癌症免疫治疗成功的核心.
- 最近的发现表明,PD-1在癌细胞内部表达和信号,这表明它有非正规的作用.
- 在各种癌症中观察到瘤内在PD-1信号,包括黑色素瘤,肝细胞癌,肺癌和结直肠癌.
研究的目的:
- 探索瘤内在PD-1信号传递的新兴范式.
- 为了澄清PD-1在癌细胞内的双重,潜在的亲或反瘤功能.
- 了解这些发现对基于抗PD-1抗体的癌症疗法的影响.
主要方法:
- 对癌细胞中PD-1表达和功能的现有文献的综述.
- 对研究瘤内在PD-1对化学抵抗和疾病复发的影响的分析.
- 关于PD-1作为促进瘤或抑制瘤的对立作用的证据综合.
主要成果:
- 有证据表明PD-1可以起到促进瘤的作用,有助于化学抵抗和瘤复发.
- 相反,其他研究表明PD-1可能具有瘤抑制功能.
- 在癌细胞中PD-1的确切功能作用尚未被确切地定义.
结论:
- 瘤内在PD-1信号的双重作用对解释对抗PD-1抗体的临床反应有重大影响.
- 治疗阻断PD-1可能会产生相反的效果:抑制促进瘤的PD-1或无意中阻断抑制瘤的PD-1.
- 需要进一步的研究来阐明PD-1的复合作用,并指导针对性临床策略的开发.
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