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Updated: Jul 22, 2025

Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications
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SUMO-NIP45途径处理有毒的DNA链,以防止线粒衰竭

Emil P T Hertz1, Ignacio Alonso-de Vega2, Thomas Kruse2

  • 1Protein Signaling Program, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark. emil.hertz@cpr.ku.dk.

Nature structural & molecular biology
|July 20, 2023
PubMed
概括

SUMOylation对于细胞增殖至关重要,可以通过NIP45和BTRR-PICH通路实现DNA连锁分离,以防止当SUMOylation被抑制时发生线粒失败.

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