持续的瘦身和神经性厌食症在基因组层面上有所不同
Christopher Hübel1,2,3,4,5, Mohamed Abdulkadir6,7, Moritz Herle8,9
1Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. christopher.huebel@ki.se.
European journal of human genetics : EJHG
|July 20, 2023
概括
持续的瘦身和神经性厌食症具有不同的遗传特征. 瘦身与精神疾病有负面的遗传关联,与神经性厌食症不同,表明基因组差异化.
科学领域:
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
- 人类生物学 人类生物学
背景情况:
- 瘦身和神经性厌食症的特点是体重低,但在身体感知和体重目标方面有所不同.
- 这两种疾病都是遗传性的,与身体质量指数 (BMI) 有着共同的遗传联系,但在遗传上彼此之间没有相关性.
研究的目的:
- 为了研究持续的瘦身和神经性厌食症之间的基因组差异.
- 为了比较瘦身和神经性厌食症与精神疾病的遗传相关性.
- 分析持久瘦身个体的遗传关联.
主要方法:
- 第1部分:使用公开可用的数据,比较持续性瘦身/神经性厌食症与11种精神疾病的遗传相关性.
- 第2部分:使用BMI (n=6594) 的潜阶级增长分析,在Avon长度家长和儿童研究 (ALSPAC) 中确定了青少年持续瘦身的个体.
- 评估了与精神病学和人类学多基因分数在持续瘦身方面的关联.
主要成果:
- 神经性厌食症与精神疾病具有积极的遗传相关性.
- 持续的瘦身表明与注意力缺陷多动症,酒精依赖,严重抑郁症和创伤后应激障碍有负面的遗传相关性.
- 持久瘦身的个体具有较低的边缘性人格障碍多基因分数.
结论:
- 与瘦身相关的遗传变异与精神疾病有负面联系.
- 基因组分析支持将瘦身与精神性厌食症区分开来.
- 研究结果强调了瘦身和神经性厌食症的独特遗传基础.
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