皮质灰质变化,睡眠障碍儿童的行为和认知 呼吸障碍儿童
Brendan Tan1, Knarik Tamanyan1, Lisa Walter1
1Department of Pediatrics, Monash University, Melbourne, Victoria, Australia.
Journal of sleep research
|July 20, 2023
概括
儿童的阻塞性睡眠呼吸障碍 (SDB) 与大脑结构变化有关,包括特定区域的皮层厚度和体积增加. 然而,这些神经发育变化似乎不会影响认知或行为结果.
科学领域:
- 神经科学是一个神经科学.
- 儿科神经学 儿科神经学
- 发育神经科学的发展神经科学.
背景情况:
- 阻塞性睡眠呼吸障碍 (SDB) 在儿童中很普遍,可能会影响神经发育.
- 以前的研究表明,SDB与认知/行为缺陷之间存在潜在联系.
研究的目的:
- 调查SDB儿童的皮质厚度和体积大脑变化.
- 探索这些结构变化与观察到的行为/认知缺陷之间的关系.
主要方法:
- 从30名儿童 (7-17岁) 收集的神经成像,行为和睡眠数据.
- 15名SDB儿童与15名不打的对照儿童进行比较.
- 基于旋转的感兴趣区域的分析,使用德西坎-基利尼地图和学生的t测试.
主要成果:
- 患有SDB的儿童在右尾前带皮带和右骨中表现出显著更大的皮质厚度.
- 在患有SDB的儿童中,在左尾部中额头部,双面正面前带和双面尾部区域观察到体积增加.
- 在结构性大脑变化和行为或认知措施之间没有发现显著的关联.
结论:
- 儿童的SDB与神经发育过程中影响特定大脑结构的中断有关.
- 尽管有结构性大脑变化,但SDB与该队列的行为或认知缺陷没有相关性.
- 需要进一步的研究才能充分理解SDB对儿科神经发育的长期影响.
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