在患有叶的儿童中,皮质皮层切除的程度
Rory J Piper1,2, Debayan Dasgupta3,4, Maria H Eriksson1,5,6
1Developmental Neurosciences Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.
Annals of clinical and translational neurology
|July 21, 2023
概括
在患有叶和海马缩症的儿童中,对皮质皮质 (PC) 进行更大切除可以改善自由度. 在没有海马缩的儿童中没有观察到这一发现,这表明不同的网络.
科学领域:
- 儿科神经学 儿科神经学
- 手术 手术 手术
- 神经成像是一种神经成像.
背景情况:
- 在成年人中,前叶切除 (ATLR) 对于药物耐药的叶 (TLE) 显示出更大的发作自由度与增加的皮质皮质 (PC) 切除.
- 没有任何儿科研究研究过这种关联.
研究的目的:
- 在接受ATLR的TLE儿童中,调查时间PC切除程度和自由度之间的关联.
主要方法:
- 儿童TLE患者接受ATLR (2012-2021) 的回顾性神经影像队列研究.
- 术前和术后的MRI用于测量PC,海马和杏仁体的体积.
- 在没有发作和没有发作的组之间比较了切除的程度.
主要成果:
- 在50名儿童中,在没有发作 (50%) 和没有发作 (40%) 组 (p=0.26) 之间,没有发现时间PC切除程度的显著差异.
- 在一个由19名患有ipsilateral海马缩的儿童组成的小组中,没有发作的患者有较大的时间PC切除 (53%) 与没有发作的儿童 (19%) (p=0.009) 相比.
结论:
- 这项研究首次表明,在患有海马缩症的儿科TLE中,更广泛的时间PC切除与更高的自由率相关.
- 没有海马缩症的儿童缺乏相关性表明,在这个人群中存在明显的发性网络.
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