可卡因使用与艾滋病毒疾病中大脑白质过强度有关
Christina S Meade1,2, Ryan P Bell1, Sheri L Towe1
1Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, 27710, USA.
Annals of clinical and translational neurology
|July 21, 2023
概括
可卡因使用和脑血管疾病风险显著预测艾滋病毒 (PWH) 感染者的白质超强度 (WMH). 解决这些因素可能有助于减轻PWH的神经认知障碍.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 白质过强度 (WMH) 在艾滋病毒 (PWH) 感染者中很常见,并预测认知能力下降.
- 在PWH中使用可卡因很普遍,可能会导致WMH.
研究的目的:
- 调查PWH中WMH负担的预测因素.
- 检查WMH负担,认知功能和生物标志物之间的关系.
主要方法:
- 接受抗逆转录病毒治疗的110名PWH接受了MRI (FLAIR,T1) 和神经心理测试.
- 使用损伤细分工具箱量化WMH负担.
- 层次回归分析了WMH的预测因素,包括人口统计,心血管疾病风险和病变负担.
主要成果:
- 可卡因使用 (29%的样本) 显著预测了更高的WMH负担 (β=.28).
- WMH负担与较差的认知功能相关 (r=-.27).
- 较高的WMH负担与IP-10和MPO水平的改变有关.
结论:
- 在PWH中,WMH负担与认知障碍有关.
- 可卡因使用和心血管疾病风险是WMH的独立贡献者.
- 管理可卡因使用和心血管疾病风险可能会减少PWH患者的脑损伤.
相关概念视频
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
242
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
242
Pulmonary Tuberculosis I
270
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
270
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K


