在认知衰退的中华纵向研究中,主观认知衰退的异质性 (SILCODE):经验性推导的亚型,结构和功能验证
Zhenrong Fu1,2, Mingyan Zhao3, Yuxia Li4,5
1Key Laboratory of Adolescent Cyberpsychology and Behavior (CCNU), Ministry of Education, Wuhan, China.
CNS neuroscience & therapeutics
|July 21, 2023
概括
主观认知衰退 (SCD) 有不同的亚型,包括dysexecutive,神经精神病和amnestic. 这些亚型表现出独特的神经成像标志物,可能表明认知衰退的不同风险.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 认知科学 认知科学
背景情况:
- 主观认知衰退 (SCD) 越来越令人担忧,但其异质性需要进一步调查.
- 了解SCD亚型对于识别患有渐进性认知衰退风险的个体至关重要.
研究的目的:
- 在认知衰退的中国纵向研究 (SILCODE) 队列中,从经验上推导主观认知衰退 (SCD) 的亚型.
- 检查与这些SCD亚型相关的神经成像标记物,生物标记物和临床结果.
主要方法:
- 对124名SCD参与者和57名正常对照 (NC) 的神经心理测试成绩进行集群分析.
- 对已识别的SCD子组进行结构和功能神经成像指数 (灰质体积,ALFF,FA) 的评估.
主要成果:
- 出现了四种亚型:双执行/混合SCD,神经精神疾病SCD,记忆障碍SCD,以及一个集群衍生的正常组.
- 与NC相比,每个SCD子组在灰质体积和低频波动幅度方面表现出不同的模式.
- 在神经精神病学SCD组中特别观察到较低的分数异构性.
结论:
- 从经验上获得的SCD亚型证实了神经心理学概况的异质性.
- 双执行性/混合性和amnestic SCD可能代表逐渐衰退的高风险群体.
- 神经精神病学SCD成为未来认知衰退研究的新领域.
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