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超声波介导的纳米尺寸药物输送系统用于癌症治疗:多尺度和多物理计算建模

Farshad Moradi Kashkooli¹, Tyler K Hornsby¹, Michael C Kolios^1,2

¹Department of Physics, Toronto Metropolitan University, Toronto, Ontario, Canada.

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

|July 21, 2023

概括

计算建模有助于优化纳米尺寸药物输送系统 (NSDDS) 用于癌症治疗. 本综述涵盖了治疗性超声波 (TUS) 介导的NSDDS的数学建模,以增强临床翻译.

科学领域:

纳米技术对生物学进行了研究.
在生物学中的纳米系统.
治疗方法和药物发现
纳米医学用于瘤疾病.

背景情况:

计算机建模对于理解抗癌药物递送系统 (DDS) 中复杂的生物现象至关重要,特别是纳米大小的DDS (NSDDS).
将NSDDS与治疗性超声波 (TUS) 的整合显示出对推进癌症治疗策略的重大前景.
通过数学建模,可以有效地实现DDS参数的优化,例如NSDDS中的参数.

研究的目的:

为癌症治疗提供TUS介导的DDS数学建模的最新进展进行了深入的审查.
讨论这些计算模型的应用,以改善TUS介导的DDS的临床翻译.
突出 in silico 建模在解决瘤药物输送中的多层次复杂问题的作用.

主要方法:

关于TUS介导的DDSs的数学建模的最新文献的审查.
对涉及声学相互作用,传热,药物释放,流体流动,质量传输和药学动力学的计算框架的分析.
讨论各种建模组件的集成,以模拟超声响应的DDS.

主要成果:

数学建模提供了一种强大的方法来优化有效NSDDS开发的参数.
在模型可以模拟复杂的现象在多尺度的药物输送问题,有助于理解和预测.
最近的进展使TUS介导的DDS能够全面建模,包括多个物理和生物过程.

结论:

数学建模对于合理设计和优化TUS介导的NSDDS是不可或缺的.
计算方法有助于改善基于TUS的癌症治疗的临床翻译.
审查强调了先进的建模技术的潜力,以推动纳米医学在瘤学的创新.

关键词:

来自纳米粒子的药物释放动力学的数学模型.多物理和多尺度计算建模.纳米尺寸的药物输送系统固体瘤是一个固体瘤.治疗性的超声波.通过超声波介导的药物输送.

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