Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
Metastasis02:30

Metastasis

5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Combining TIGIT Blockade with MDSC Inhibition Hinders Breast Cancer Bone Metastasis by Activating Antitumor Immunity.

Cancer discovery·2024
Same author

Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary.

Cancer discovery·2023
Same author

Breast Cancer-Secreted Factors Promote Lung Metastasis by Signaling Systemically to Induce a Fibrotic Premetastatic Niche.

Cancer research·2023
Same author

Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis.

Cancer discovery·2023
Same author

Reciprocal interactions between innate immune cells and astrocytes facilitate neuroinflammation and brain metastasis via lipocalin-2.

Nature cancer·2023
Same author

Chemotherapy-induced complement signaling modulates immunosuppression and metastatic relapse in breast cancer.

Nature communications·2022

相关实验视频

Updated: Jul 22, 2025

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.5K

位置,位置:了解转移的微环境.

Neta Erez1

  • 1Department of Pathology, Faculty of Medicine, Tel Aviv University, Israel.

Molecular oncology
|July 21, 2023
PubMed
概括

了解瘤转移,癌症死亡的主要原因,需要研究癌细胞如何适应器官特定的微观环境. 研究正在探索这些相互作用,以防止癌症复发.

科学领域:

  • 在瘤学瘤学.
  • 癌症生物学 癌症生物学
  • 微环境研究 微环境研究

背景情况:

  • 瘤转移是癌症相关死亡的主要原因,而晚期转移性癌症目前无法治愈.
  • 瘤微环境在瘤生长中的作用已经确立,但其在支持转移的多阶段过程中的功能仍然在很大程度上是未知的.
  • 扩散的癌细胞必须适应独特的器官特异性微环境,以在转移部位生存和生长.

研究的目的:

  • 研究转移性微环境在支持瘤转移中的关键作用.
  • 阐明扩散癌细胞和器官特异性微观环境之间的细胞和分子相互作用.
  • 在转移性微环境中确定影响癌细胞适应和生长的关键因素.

主要方法:

  • 这项研究的重点是了解涉及的生物过程,而不是特定的实验方法.
  • 审查和综合现有关于瘤转移和瘤微环境的研究.
  • 在转移部位的细胞和分子相互作用的分析.

主要成果:

  • 转移性微环境在瘤转移的多阶段过程中起着至关重要的,但尚未研究的作用.
  • 器官特异性微环境为扩散的癌细胞带来了独特的挑战和支持机制.
  • 成功适应转移性微环境对于癌细胞的生存和生长至关重要.
关键词:
转移 转移 转移 转移转移的转移性利基微观环境是一个微观环境.一个特定器官的特定器官.

更多相关视频

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
09:44

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Published on: June 13, 2016

8.5K
Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
09:42

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis

Published on: June 26, 2019

8.9K

相关实验视频

Last Updated: Jul 22, 2025

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.5K
Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
09:44

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Published on: June 13, 2016

8.5K
Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
09:42

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis

Published on: June 26, 2019

8.9K

结论:

  • 了解转移性微环境中的复杂相互作用对于开发有效的治疗策略至关重要.
  • 针对这些微环境相互作用可以预防转移性复发并改善患者的治疗结果.
  • 对特定器官的转移性微环境进行进一步的研究是必要的,以打击癌症死亡率.