骨肌肉脂肪是非洲加勒比地区妇女认知能力差的一个新风险因素
Adrianna I Acevedo-Fontánez1, Ryan K Cvejkus1, Joseph M Zmuda1
1Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Obesity (Silver Spring, Md.)
|July 21, 2023
概括
骨肌脂肪增加 (骨髓瘤) 与老年妇女的信息处理速度减慢有关. 这一发现表明,与骨髓炎相关的认知障碍的潜在早期指标.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
背景情况:
- 骨肌脂肪 (骨髓瘤) 是心脏代谢疾病的重要危险因素,并且随着年龄的增长而恶化.
- 骨髓炎和认知障碍之间的联系在很大程度上仍未被探索.
研究的目的:
- 调查非洲加勒比地区妇女的小牛骨髓炎和认知功能之间的关联,该人口容易增加骨髓炎.
- 为了检查骨肌肉密度和信息处理速度之间的关系.
主要方法:
- 这项研究包括626名40-84岁的非洲加勒比地区妇女.
- 用计算机断层扫描获得的骨肌肉密度来评估小牛骨髓炎.
- 用数字符号替换测试 (DSST) 测量认知功能,评估信息处理速度.
主要成果:
- 肌肉密度下降的一个标准偏差与DSST得分下降1.69点有关 (p=0.002),在调整多个共同变量后.
- 这种关联并没有受到BMI,糖尿病或高血压的显著缓解.
结论:
- 较大的骨髓炎与较慢的信息处理速度有关,这是认知能力下降的早期迹象.
- 需要进一步的研究来证实这些发现在不同种群中,并探索潜在的生物机制.
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