背上条纹体对味道的反应受到肥胖和胰岛素抵抗的改变
Julia P Dunn1,2, Bidhan Lamichhane3, Gordon I Smith2
1VA St. Louis Health Care System, St. Louis, Missouri, USA.
Obesity (Silver Spring, Md.)
|July 21, 2023
概括
背上条纹体 (DS) 中央胰岛素抵抗会改变大脑对味道的反应,这可能会阻碍减肥. 减肥部分改善了肥胖个体的这些异常反应.
科学领域:
- 神经科学是一个神经科学.
- 代谢研究研究 代谢研究
- 肥胖研究 肥胖研究
背景情况:
- 背上条纹体 (DS) 中的胰岛素耐药性与临床前模型中的过度饮食有关.
- 人类研究表明中央胰岛素抵抗,但其对奖励诱导的大脑活动的影响仍然未被探索.
研究的目的:
- 为了研究中央胰岛素抵抗对大脑活动的影响,以响应人类的味道.
- 为了比较瘦,代谢健康的肥胖和代谢不健康的肥胖个体的味道诱导的大脑激活.
主要方法:
- 使用血氧水平依赖 (BOLD) 功能磁共振成像 (fMRI) 来评估DS (尾皮和皮) 中的口味诱导激活.
- 研究了三个组:代谢健康的瘦身,代谢健康的肥胖和代谢不健康的肥胖 (MUO).
- MUO参与者接受了减肥干预,随后进行了第二次fMRI扫描.
主要成果:
- 在各组中观察到BOLD反应的显著差异:在瘦身者中呈阳性,在MUO中呈阴性,在代谢健康的肥胖者中呈中等.
- 味觉诱导的激活预测了对食物的渴望.
- 在减肥后,MUO组在DS中表现出增加的味道诱导激活.
结论:
- 肥胖和胰岛素抵抗有助于DS患者的异常味觉反应.
- 减肥只能部分扭转这些异常反应,这表明它们可能会阻碍体重管理的努力.
相关概念视频
Taste Buds and Receptors
2.2K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
2.2K
Regulation of Food Intake
288
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
288
Conditioned Taste Aversion
181
Conditioned taste aversion, also known as sauce béarnaise syndrome, is a phenomenon in which an individual develops an aversion to a certain food taste following a negative experience, typically illness. This form of aversion is a type of classical conditioning in which the taste of the food (conditioned stimulus, CS) is associated with the experience of illness (unconditioned stimulus, UCS).
A notable characteristic of conditioned taste aversion is that it often requires only a single...
A notable characteristic of conditioned taste aversion is that it often requires only a single...
181
The Physiology of Taste
4.0K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
4.0K
Carbohydrate Metabolism
11.3K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.3K
Gustation
48.2K
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
48.2K


