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在前性,受控的瑞典肥胖受试者研究中,减肥手术后非酒精物质使用障碍
Per-Arne Svensson1,2, Markku Peltonen3, Johanna C Andersson-Assarsson1
1Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Obesity (Silver Spring, Md.)
|July 21, 2023
概括
胃绕道手术与非酒精物质使用障碍 (SUD) 的更高风险有关. 这一发现凸显了需要仔细长期监测患者的需要,这种减肥手术后.
科学领域:
- 腹腔外科手术的结果
- 药物使用障碍研究 药物使用障碍研究
- 肥胖治疗并发症 肥胖治疗并发症
背景情况:
- 减肥手术是严重肥胖的常见治疗方法.
- 减肥手术对物质使用障碍 (SUD) 的长期影响尚未完全理解.
- 之前的研究并没有广泛地检查不同减肥手术后的非酒精SUD.
研究的目的:
- 调查减肥手术与非酒精物质使用障碍 (SUD) 的发生率之间的关联.
- 为了比较不同减肥手术 (胃绕道手术,垂直带式胃整形手术,胃带) 和对照组的非酒精SUD风险.
- 确定可能增加非酒精性SUD风险的特定减肥程序.
主要方法:
- 潜在的,受控的瑞典肥胖患者研究,包括2010年减肥手术患者和2037匹配的对照.
- 随访时间中位数为23.8年,使用国际疾病统计分类 (ICD) 代码识别非酒精SUD.
- 排除以前有非酒精性SUD史的参与者.
主要成果:
- 胃绕道与非酒精性SUD的发生率显著增加有关 (调整后的危险比值为2.54).
- 无酒精SUD的每1000人年发病率为1.6 (胃绕道),0.8 (垂直带式胃整形),1.1 (胃带) 和0.6 (对照组).
- 与对照组相比,垂直带式胃整形和胃带并没有显示出与非酒精SUD增加的统计学上显著的关联.
结论:
- 胃绕道手术与发展非酒精物质使用障碍 (SUD) 的风险增加有关.
- 医疗保健提供者应考虑在经过胃绕道术的患者的长期术后护理中增加这种风险.
- 进一步的研究可能是有必要的,以了解这种关联背后的机制,并制定有针对性的干预措施.
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