在怀孕中与没有SARS-CoV-2感染的怀孕中比较临床和胎盘病理特征
Yasminur Gabdulhakovna Turdybekova1, Irina L Kopobayeva1, Yevgeniy K Kamyshanskiy1
1Medical University of Karaganda, Karaganda, Kazakhstan.
Journal of perinatal medicine
|July 21, 2023
概括
高风险怀孕中严重的SARS-CoV-2感染与严重的胎盘损伤和不良结果有关. 多种疾病增加了风险,强调了针对这些孕妇的有针对性的监测和预防策略的需要.
科学领域:
- 产周医学 产周医学
- 传染病病理学 传染病病理学
- 产科 产科 产科 产科 产科
背景情况:
- 高风险怀孕需要仔细监测,特别是在病毒爆发期间.
- SARS-CoV-2 感染对母亲-胎盘-胎儿系统的影响是研究的一个关键领域.
- 了解COVID-19中的胎盘病理对于改善围产期结果至关重要.
研究的目的:
- 为了比较高风险怀孕中母亲-胎盘-胎儿系统的临床和形态特征,没有,轻度和严重的SARS-CoV-2感染.
- 调查SARS-CoV-2严重程度,母亲的并发症和胎盘病理之间的关联.
- 确定COVID-19感染孕妇不良周产期结果的危险因素.
主要方法:
- 一项涉及高风险怀孕的病例对照研究,怀孕28周或更早分娩.
- 胎盘病理检查使用标准处理和血素和欧染色.
- 三组的比较:没有SARS-CoV-2感染,轻微的SARS-CoV-2感染和严重的SARS-CoV-2感染.
- 使用SPSS进行的统计分析,p<0.05被认为是显著的.
主要成果:
- 严重的SARS-CoV-2感染与孕妇多病症 (糖尿病,高血压,肥胖) 的增加有关.
- 严重的COVID-19病例的胎盘与轻度和对照组相比,显示出显著的慢性和急性损伤.
- 状 trofhoblast 的扩散性亡,包括同质化和eosinophilic 质量,是严重的COVID-19 胎盘的一个关键发现.
结论:
- 患有多种疾病的女性患有严重的SARS-CoV-2感染,胎盘损伤和围产期缺氧-缺血事件的风险更高.
- 患者教育,疾病监测和预防措施对于这个高风险子组至关重要.
- 在患有并发症的孕妇中早期识别和治疗SARS-CoV-2可以减轻不良结果.
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