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在MMP-9和缺血性中风易感性之间存在潜在的关系rs2250889

Hanming Ge¹, Xiaojuan Ma², Jiachen Wang³

¹Department of Neurology, Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.

Frontiers in neurology

|July 21, 2023

概括

矩阵金属化酶9 (MMP-9) 基因的遗传变异,特别是SNP rs2250889,与缺血性中风 (IS) 的风险增加有关. 这一发现有助于理解对IS的遗传倾向.

科学领域:

遗传学遗传学是一种遗传学.
神经学神经学
分子生物学分子生物学

背景情况:

缺血性中风 (IS) 是一种严重的脑血管疾病,具有相当大的健康影响.
遗传因素在IS的发展中起着至关重要的作用.
矩阵金属化酶9 (MMP-9) 基因与IS的病理生理学有关,并作为潜在的生物标志物.

研究的目的:

调查矩阵金属化酶9 (MMP-9) 基因多态化与缺血性中风 (IS) 易感性之间的关联.
在MMP-9基因内识别可能影响IS风险的特定单核酸多态 (SNPs).

主要方法:

在700名IS患者和700名使用MassARRAY的健康对照中,对MMP-9基因单核酸多态 (SNPs) 的基因定型.
应用多因素缩小维度 (MDR) 来分析SNP-SNP相互作用.
对等位基因和基因型频率,几率比率 (ORs) 和95%置信区间 (CI) 的统计分析以评估IS易感性.

主要成果:

在MMP-9基因中的SNPrs2250889与多个遗传模型 (共主导,主导,超主导,日志添加) 的IS易感性增加有显著关联.
分层分析显示,rs2250889与基于年龄,性别 (女性),吸烟状态和酒精消费 (不饮酒) 的子组中的IS风险有关.
在MDR分析中,rs2250889被确定为IS风险最具预测性的模型,交叉验证一致性为10/10和OR为1.56.

结论:

这项研究提供了初步证据,证实了MMP-9基因多态 rs2250889和易患缺血性中风之间的显著联系.
这些发现突显了MMP-9遗传变异在IS病因学中的潜在作用.

关键词:

在MMP-9中,它是MMP-9的.在SNP中,SNP是SNP.个案控制研究研究.缺血性中风中风易感性易感性易感性

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