评估美国成年人的挥发性有机化合物暴露和慢性阻塞性肺部疾病
Jia-Jie Lv1,2, Xin-Yu Li1,3, Yu-Chen Shen1
1Department of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Frontiers in public health
|July 21, 2023
概括
暴露于和o-xylen等挥发性有机化合物 (VOC) 与COPD风险增加有关. 这些VOC的特定血液度与最高风险相关,突出了潜在的预防目标.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 肺部医学 肺部医学
背景情况:
- 挥发性有机化合物 (VOC) 在日常生活中普遍存在,证据表明累积毒性.
- 挥发性有机化合物暴露与慢性阻塞性肺病 (COPD) 风险之间的关联仍未得到报道.
研究的目的:
- 综合评估血液中挥发性有机化合物的度与患上COPD的风险之间的关联.
- 确定特定的VOC及其与COPD风险增加相关的水平.
主要方法:
- 来自国家健康和营养检查调查的1477名受试者的分析.
- 利用多重回归模型和平滑曲线拟合 (惩罚线) 来评估关联.
- 进行了分层分析,以确定高风险的人口群体.
主要成果:
- 血液中的和o-xylen度与COPD风险之间发现了积极的关联.
- 在血液中的度为0.28 ng/mL和o-xylene度为0.08 ng/mL时,观察到COPD的最高风险.
- 性别,年龄和代谢等效任务 (MET) 被确定为影响因素,特别是在女性,年轻人和低MET的人群中.
结论:
- 血液中的和o-xylene独立且与COPD风险有积极的相关性.
- 长期暴露于和o-xylene可能会导致肺部疾病.
- 建立了用于COPD预防策略的新参考血液VOC度.
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