消化系统神经内分泌瘤免疫疗法的进展
Wei-Xuan Pan1, Xin-Mu Zhang2, Shao-Long Hao1
1Department of General Surgery, Beijing Luhe Hospital, Capital Medical University, Beijing 101100, China.
World journal of gastroenterology
|July 21, 2023
概括
免疫检查点抑制剂 (ICI) 对晚期神经内分泌瘤 (NENs) 是有前途的,特别是在组合疗法中. 进一步的研究正在探索它们在消化系统中的有效性和最佳使用NENs.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 胃肠病学 胃肠病学
背景情况:
- 神经内分泌瘤 (NEN) 是一种罕见的,异质的瘤,主要影响消化器官.
- 目前对晚期NEN的治疗方法有限,尽管初始疗法取得了进展.
- 免疫检查点抑制剂 (ICI) 在一些固体瘤中有效,但在大多数NEN中应用有限.
研究的目的:
- 审查免疫治疗在消化系统中的临床进展NENs.
- 为了强调编程细胞死亡蛋白1/编程死亡受体连接体1 (PD-1/PD-L1) 抑制剂的作用.
- 探索潜在的患者群体和免疫治疗在NEN管理中的价值.
主要方法:
- 对临床试验和关于NENs免疫疗法的研究的综合文献综述.
- 专注于编程细胞死亡蛋白1/编程死亡受体连接体1 (PD-1/PD-L1) 抑制剂.
- 综合疗法与单一疗法的疗效分析.
主要成果:
- 最近的试验表明,对于某些NENs,组合免疫疗法比单疗法更有效.
- 目前正在进行的临床试验正在评估各种ICI组合疗法的安全性和有效性.
- PD-1/PD-L1 抑制剂代表了对NENs的有前途的治疗途径.
结论:
- 免疫疗法,特别是与ICI结合治疗,对于治疗先进的消化系统NENs具有显著的潜力.
- 确定适合免疫治疗的患者群体对于最大限度地提高治疗效益至关重要.
- 对PD-1/PD-L1抑制剂的进一步研究对于NEN管理是有必要的.
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