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非洲裔美国人中的脂肪,阿尔多和血仁素活性:杰克逊心脏研究

Grace Lee¹, Bjorn Kluwe¹, Songzhu Zhao²

¹Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, USA.

Endocrine and metabolic science

|July 21, 2023

概括

像BMI和瘦素这样的肥胖指标与非裔美国人的氨酸-血管氨酸-阿尔多斯特系统 (RAAS) 有关. 这些协会强调RAAS RAAS.

科学领域:

心血管科学心血管科学
代谢健康代谢健康
内分泌学在内分泌学.

背景情况:

氨酸- ангиотензин- алдостерон系统 (RAAS) 在血压调节和液体平衡中起着至关重要的作用.
肥胖是心脏代谢疾病的已知风险因素,其与RAAS的关系复杂,需要进一步调查,特别是在多样化的群体中.
非洲裔美国人 (AA) 患肥胖和相关并发症的患病率较高,使他们成为研究这些关联的关键人口.

研究的目的:

在一大批非裔美国人中,研究各种脂肪度量和RAAS的关键组成部分之间的横截面关联.
为了确定哪些特定的脂肪指标显示与阿尔多斯最强的联系,血胆固醇活性,以及阿尔多斯胆固醇-胆固醇比率 (ARR).

主要方法:

杰克逊心脏研究队列被用于此横截面分析.
评估了多种脂肪标志物,包括体重指数 (BMI),腰围 (WC),瘦素,脂肪素,瘦素:脂肪素比率 (LAR),皮下脂肪组织 (SAT),内脏脂肪组织 (VAT) 和肝脏衰减 (LA).
调整后的线性回归模型被用于分析与阿尔多斯激素,血雷宁活性 (renin) 和ARR的关联.

主要成果:

较高的体重指数 (BMI) 与阿尔多和氨酸水平的增加以及ARR的降低显著相关.
洛格-莱普与素有强烈的积极关联,与ARR有负面关联,而洛格-LAR与阿尔多素最强烈相关.
内脏脂肪组织 (VAT) 与较高的阿尔多素,氨酸和ARR有关,而皮下脂肪组织 (SAT) 仅与氨酸有关. 肝脂肪与阿尔多和氨酸有关联,但没有ARR.
观察到性别特异性差异,男性中WC,BMI和SAT与阿尔多斯激素的关联较强,女性中VAT关联较强.

结论:

这项研究证实,多种衡量脂肪的方法与非裔美国人的RAAS有显著的关联.
这些发现强调了考虑不同的脂肪储存和它们与RAAS组件的独特关系的重要性.
需要进一步的研究来阐明RAAS在这个人群中与肥胖有关的心脏代谢疾病中的作用.

关键词:

脂肪组织的脂肪组织.非洲裔美国人.阿尔多氨酸是一种阿尔多氨酸.雷宁雷宁是什么意思

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