单细胞转录基因组分析揭示了骨髓系衍生抑制细胞在头部和部状细胞癌的临床含义
Wenru Jiang1, Kangyao Hu1, Xiaofei Liu1
1Department of Implant and Prosthodontics, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Pathology oncology research : POR
|July 21, 2023
概括
骨髓系衍生抑制细胞 (MDSCs) 是头部和部状细胞癌 (HNSC) 的关键. 针对MDSC及其相关基因显示出改善HNSC免疫疗法和患者生存结果的希望.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 基因组学就是基因组学.
背景情况:
- 头部和部状细胞癌 (HNSC) 是一种常见的恶性瘤.
- 骨髓系衍生抑制细胞 (MDSCs) 是瘤微环境中的关键免疫抑制剂.
- 了解髓状细胞异质性对于HNSC治疗策略至关重要.
研究的目的:
- 研究骨髓状细胞,特别是MDSCs在HNSC中的作用.
- 为了确定HNSC患者生存期的预后标记.
- 探索涉及HNSC中MDSC的细胞间通信网络.
主要方法:
- 单细胞RNA测序 (scRNA-seq) 用于分析髓状细胞异质性.
- 大量RNA-seq解卷,以评估MDSC透和患者预后.
- 与MDSCs相关的六基因预后签名的识别和验证.
- 通过CellChat分析,绘制MDSC与其他细胞之间的联体受体相互作用.
主要成果:
- 瘤相关巨细胞 (TAMs) 和MDSCs是最丰富的髓状细胞.
- 高MDSC透与HNSC患者的整体存活率 (OS) 较差相关.
- 一个六个基因的签名 (ALDOA,CD52,FTH1,RTN4,SLC2A3,TNFAIP6) 有效地预测了患者的预后.
- MDSC与CD8+ T细胞,TAM细胞和内皮细胞相互作用,促进免疫抑制和血管生成.
结论:
- 在HNSC中,MDSCs是一个显著的不良预后标志物.
- 鉴定的六基因特征为预测HNSC患者的结果提供了一个有希望的工具.
- 针对MDSCs为HNSC免疫疗法提供了一个潜在的治疗策略.
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