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相关概念视频

Multicompartment Models: Overview01:14

Multicompartment Models: Overview

183
Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
183
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

573
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
573
Compartment Models: Single-Compartment Model01:14

Compartment Models: Single-Compartment Model

2.3K
The single-compartment model serves as a simplified representation of the human body. This model assumes that the body functions as a single, well-mixed open compartment. When a drug is administered intravenously, it enters the body and quickly distributes uniformly. The drug then undergoes biotransformation and elimination, ultimately leaving the body. The volume of this compartment is referred to as the apparent volume of distribution into which the drug can uniformly distribute. In this...
2.3K
Compartment Models: Two-Compartment Model01:20

Compartment Models: Two-Compartment Model

5.7K
The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...
5.7K
Three-Compartment Open Model01:06

Three-Compartment Open Model

281
The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...
281
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model01:13

Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model

95
Drugs administered through various routes can lead to nonlinear elimination, resulting in complex pharmacokinetic behaviors crucial to understanding efficacious drug dosing.
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
95

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相关实验视频

Updated: Jul 22, 2025

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials
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一种混合虚拟元素方法用于Biot的整合模型.

Feng Wang1, Mingchao Cai2, Gang Wang3

  • 1Jiangsu Key Laboratory for NSLSCS, School of Mathematical Sciences, Nanjing Normal University, Nanjing 210023, China.

Computers & mathematics with applications (Oxford, England : 1987)
|July 21, 2023
PubMed
概括
此摘要是机器生成的。

本研究介绍了一个弱虚拟元件方法,用于测量弹性问题. 新方法在网格大小和时间步骤方面实现了最佳的融合率,为复杂的模拟提供了可靠的解决方案.

关键词:
孔弹性方程 孔弹性方程虚拟元素方法 虚拟元素方法弱小的加勒金金.

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科学领域:

  • 计算力学是计算力学.
  • 地质物理学 地质物理学
  • 应用数学 应用数学 应用数学

背景情况:

  • 孔弹性问题在地球物理学和工程学中至关重要.
  • 现有的数值方法面临着复杂的几何形状和异质材料的挑战.
  • 需要有效和准确的计算技术来模拟流体流动和固体变形.

研究的目的:

  • 开发和分析一个新的虚弱元件方法 (WVEM) 用于三场电流弹性问题.
  • 在一般的多层状网格上分离弹性方程.
  • 确定拟议的数值方案的收性质.

主要方法:

  • 虚弱虚拟元素方法用于空间离散.
  • 低级虚拟元素大致表示流速和压力.
  • 具有触角多项式的高阶虚拟元素可以分辨弹性位移.
  • 倒向欧勒方案用于时间离散.

主要成果:

  • 完全离散的方案在视网格大小方面达到1的趋同顺序.
  • 时间步骤也产生了1的收顺序.
  • 收分析中的隐常数是独立于问题参数的.
  • 数学实验验证实了理论上的收率.

结论:

  • 拟议的虚弱元素方法是有效的解决三个领域的多弹性问题.
  • 该方法证明了最佳的融合,为计算地质物理学和工程提供了可靠的工具.
  • 该技术适用于复杂的多层状网格,增强模拟能力.