在COVID-19患者中评估甲状腺功能测试
Cemalettin Durgun1, Mehmet Durgun2
1General Surgery, Memorial Dicle Hospital, Diyarbakır, TUR.
Cureus
|July 21, 2023
概括
甲状腺激素水平,包括自由三甲状腺素 (fT3) 和自由甲状腺素 (fT4),与COVID-19的严重程度和死亡率有显著的相关性. 较低的甲状腺激素水平表明COVID-19患者的预后较差.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- SARS-CoV-2 感染会影响下丘脑-垂体-甲状腺轴,影响甲状腺功能.
- 在COVID-19患者中,甲状腺对直接病毒感染和荷尔蒙变化的敏感性得到了认可.
- 对于病毒进入至关重要的ACE2受体,在甲状腺中大量存在.
研究的目的:
- 研究甲状腺功能测试在预测COVID-19结果中的预后价值.
- 分析住院COVID-19患者的甲状腺激素水平和疾病严重程度之间的关系.
- 为了确定甲状腺功能测试是否可以预测COVID-19的重症监护室 (ICU) 患者的死亡率.
主要方法:
- 研究了一组146名患有COVID-19且以前没有甲状腺疾病的ICU患者.
- 评估了甲状腺激素水平 (fT3,fT4),C反应蛋白 (CRP),D-二聚体和费里丁.
- 根据治疗反应,患者被分为康复 (I组) 和死亡 (II组) 组.
主要成果:
- 观察到FT3和FT4的水平降低,COVID-19的严重程度增加,特别是在未康复的患者 (II组) 中.
- 在康复和死亡组之间发现了FT3和FT4水平的统计学上显著差异 (P = 0.015和P = 0.004).
- 升高的CRP,D-二聚合物和费里水平也显示了两组之间显著的差异 (分别P=0.036,P=0.022和P<0.000).
结论:
- 甲状腺激素水平是COVID-19患者的关键预后指标.
- 甲状腺功能的变化,特别是fT3和fT4的减少,与疾病严重程度和死亡率的增加有关.
- 甲状腺功能测试表明,在预测COVID-19患者的死亡风险方面具有潜在的实用性.
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