在患有COVID-19后急性后果的个体中持续的氧化应激
Muhammad G Saleh1, Linda Chang1,2,3, Huajun Liang1
1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
概括
患有COVID-19 (PASC) 后急性后遗症的个体表现出较低的大脑谷氨酸 (GSH) 水平,表明正在进行的氧化应激. 患有PASC的老年人可能更容易受到这种大脑氧化应激.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 传染性疾病 传染性疾病
背景情况:
- 由于氧化应激,COVID-19 (由SARS-CoV-2引起) 与血谷氨 (GSH) 的减少有关,这是一种关键的抗氧化剂.
- 血GSH水平可能不准确地代表大脑GSH度.
- COVID-19 (PASC) 后急性后果往往涉及认知疲劳,可能与改变的大脑神经递质水平 (如胺黄油酸 (GABA)) 有关.
研究的目的:
- 在经历COVID-19 (PASC) 后急性后续症状的个体中调查大脑谷氨 (GSH) 和胺黄油酸 (GABA) 水平.
- 探索PASC,认知疲劳和大脑中神经化学变化的关系.
主要方法:
- 招募了29名PASC参与者和24名健康对照人进行详细的神经心理评估.
- 使用编辑的质子磁共振光谱 (MRS) 方法 (HERMES) 来量化GABA和GSH度.
- 在大脑前部灰质 (GM) 和白质 (WM) 区域测量神经化学水平.
主要成果:
- 帕斯克参与者在COVID-19诊断后平均有219天;9人住院治疗.
- 在PASC参与者和对照者之间,在大脑GABA水平上没有明显的差异.
- 与对照组相比,PASC参与者表现出较低的前额灰质GSH水平,以及与年龄相关的GSH下降幅度较大.
结论:
- 在PASC中减少的前额灰质GSH表明大脑内持续的氧化应激.
- 患有PASC的老年人似乎更容易受到这种持续的大脑氧化应激的影响.
- 这些发现突出了PASC认知症状的潜在神经化学基础.
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