与高卡路里饮食接触相关的习惯性行为被素受体-1抗剂阻止
Sam Merlin1, Teri M Furlong2,3
1School of Science, Western Sydney University, Campbelltown, NSW 2560, Australia.
Addiction neuroscience
|July 21, 2023
概括
用SB-334867准素受体-1 (ORX-R1) 减少了暴露在高热量饮食中的老鼠寻找食物的习惯性. 这一发现意味着黑体和横向下丘脑在习惯形成中,为强迫性食障碍提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 与成相关的习惯性行为,在高卡路里饮食 (HCD) 暴露后,损害了寻找食物的控制.
- 素受体-1 (ORX-R1) 反对作用影响刺激驱动的食,但其在习惯性行为中的作用尚不清楚.
研究的目的:
- 研究ORX-R1对抗在调节习惯性寻找食物中的作用.
- 为了确定ORX-R1对抗性是否可以恢复HCD诱导的习惯的老鼠的目标导向行为.
主要方法:
- 雄性Long-Evans老鼠接受了类似暴饮暴食的HCD或食访问,随后进行了杆压力训练.
- 结果值测试评估了以目标为导向的行为与习惯性的行为.
- 进行了ORX-R1抗剂SB-334867的全身和内内给药.
主要成果:
- 暴露于HCD的老鼠表现出习惯性的行为,而吃的老鼠表现出目标导向的行为.
- 系统性SB-334867的管理恢复了HCD暴露的老鼠的目标导向行为.
- 内黑内SB-334867还恢复了目标导向的行为,涉及黑色物质.
结论:
- 准ORX-R1有效地减少了雄性大鼠的习惯性寻找食物.
- 这项研究涉及黑体和横向下丘脑在习惯表达的神经回路中.
- 这些发现可能会为强迫性食,肥胖和暴饮暴食障碍的治疗提供信息.
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