在帕金森病中扎:最新消息
Rajasumi Rajalingam1,2, Alfonso Fasano1,3,4
1Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic Toronto Western Hospital, UHN Toronto Ontario Canada.
Movement disorders clinical practice
|July 21, 2023
概括
在帕金森病 (PD) 中的冲击与多巴胺治疗,年轻年龄,男性性别和疾病严重程度有关. 先进的神经成像显示大脑连接受损,一些治疗方法提供暂时的缓解.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 撞击是一种重复的,非目标导向的行为,在接受多巴胺替代疗法 (DRT) 的帕金森病 (PD) 患者中观察到.
- 2010年之前的研究建立了对分析病理生理学的初步审查.
- 这项研究系统地审查了过去十年 (2010-2022) 关于PD的分析的文献.
研究的目的:
- 系统地审查帕金森病的临床特征.
- 阐明分析的潜在病理生理机制.
- 识别和审查目前的治疗策略.
主要方法:
- 在PubMed,Embase和APA PsycInfo数据库上进行系统的文献搜索.
- 搜索标准包括2010年7月1日至2022年3月19日期间发表的文章,使用关键词 (punding) 和 (parkinson*).
- 遵守系统审查和元分析 (PRISMA) 准则的首选报告项目.
主要成果:
- 包括29项研究,包括19篇原创研究文章和10篇案例报告.
- 分析的预测因素包括更高的DRT剂量,年轻的年龄,男性性别和疾病严重程度的增加.
- 神经成像表明,评判与中脑,边缘和前脑通路的连接中断有关,特别是在奖励回路内.
- 发现了评价和精神病/认知症状之间的关联.
- 重复的横磁性刺激 (rTMS) 显示了暂时的益处.
结论:
- 在PD中分析的临床特征已经得到了很好的确立.
- 在了解丁病理生理学方面取得了重大进展,这在很大程度上是由于MRI技术.
- 对有效的长期治疗的进一步研究是有必要的.
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