呼吸道肌肉力量训练在多系统缩:一个试点研究研究
Martin Srp1, Tereza Bartosova1, Jiri Klempir1
1Department of Neurology and Centre of Clinical Neuroscience First Faculty of Medicine, Charles University and General University Hospital in Prague Prague Czech Republic.
Movement disorders clinical practice
|July 21, 2023
概括
呼吸道肌肉力量训练 (EMST) 改善了多重系统缩 (MSA) 患者的最大呼吸压力,但没有显著改变自愿性峰值咳流. 肺功能障碍指数显示出确定MSA中咳障碍的希望.
科学领域:
- 神经学 神经学
- 肺部病理学 肺部病理学
- 康复医学 康复医学 康复医学
背景情况:
- 多种系统缩 (MSA) 是一种神经退行性疾病,影响多种身体功能.
- 呼吸道肌肉衰弱是MSA患者常见但未得到充分研究的问题.
- 呼吸道肌肉力量训练 (EMST) 对MSA呼吸功能的影响以前没有被研究过.
研究的目的:
- 评估一个为期8周的家庭EMST计划对MSA患者的呼吸肌肉强度和自愿峰值咳流量 (vPCF) 的影响.
- 评估肺功能障碍指数在识别MSA患者的肺部功能障碍指数的有用性,这些患者有呼吸道肌肉衰弱和减少vPCF.
主要方法:
- 这是一项开放的,非受控的研究,涉及15名MSA患者.
- 一个为期8周的密集家庭EMST协议.
- 在干预前后测量最大呼气压 (MEP) 和vPCF.
- 接收器操作特征 (ROC) 分析,以评估肺功能障碍指数的诊断准确性.
主要成果:
- 在15名注册的MSA患者中,12名完成了EMST协议.
- 在培训后观察到MEP的统计学上显著增加 (P = 0.006).
- 在EMST8周后,没有发现vPCF的显著差异 (P = 0.845).
- ROC分析表明,肺功能障碍指数在检测无效咳的风险患者方面具有卓越的准确性,并且在检测出口肌肉强度下降方面具有可接受的准确性.
结论:
- 八周的EMST并没有导致MSA患者的vPCF显著改善.
- 肺功能障碍指数是一种潜在的有价值的查工具,用于识别MSA中的咳功能障碍.
- 该指数的特定切断值可以指导MSA患者选择适当的呼吸系统物理治疗干预措施.
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