在患有帕金森病和排便功能障碍的患者中对直肠计量学的不同发现
Wendy Zhou1, George Triadafilopoulos1, Brooke Gurland1
1Division of Gastroenterology and Hepatology Stanford University School of Medicine Stanford CA USA.
Movement disorders clinical practice
|July 21, 2023
概括
便秘在帕金森病 (PD) 中很常见. 高分辨率门测量 (HR-ARM) 揭示了大多数PD患者,特别是女性的门缺陷和异常排便协调.
科学领域:
- 胃肠病学 胃肠病学
- 神经学 神经学
- 生理学 生理学 生理学
背景情况:
- 便秘是帕金森病 (PD) 的一个常见的非运动性症状.
- 直肠功能障碍对PD患者的胃肠道问题有显著的贡献.
研究的目的:
- 在帕金森病患者中识别高分辨率直肠测量 (HR-ARM) 异常.
- 用标准化的伦敦分类来对这些异常进行分类.
主要方法:
- 对36名帕金森病患者进行HR-ARM和气球驱逐试验 (BET) 进行便秘的回顾性审查.
- 使用伦敦分类标准重新分析HR-ARM数据.
- 统计分析包括威尔科克森的等级和费舍尔的精确测试.
主要成果:
- 根据伦敦分类,门缺陷 (47%) 和门低血压 (19%) 是最常见的HR-ARM发现.
- 在61%的患者中,异常的BET与异能发生.
- 女性表现出更高的门缩率,而男性表现出更具悖论性的门收缩.
结论:
- 阳门疾病在帕金森病患者中非常普遍.
- 部缺性和异常排便协调是PD的关键发现.
- 需要进一步的研究,以澄清女性PD患者部缺约率的更高发病率.
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