过去,现在和未来的乙型肝炎病毒的长期治疗
Teresa Broquetas1,2, José A Carrión1,2,3
1Liver Section, Gastroenterology Department, Hospital del Mar, Barcelona 08003, Spain.
World journal of gastroenterology
|July 21, 2023
概括
乙型肝炎病毒 (HBV) 感染影响全球3.16亿人. 虽然核类相似物 (NA) 能够治疗慢性HBV,但新的组合疗法正在出现,以实现对这种主要肝病的功能治疗.
科学领域:
- 肝病学和病毒学.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 慢性乙型肝炎病毒 (HBV) 感染影响全球3.16亿人,导致肝硬化和肝细胞癌 (HCC).
- 核类相应物 (NA) 是当前治疗慢性HBV的标准,有效控制病毒复制并减缓疾病进展.
- 尽管NA有效,但HBV表面抗原血清清除率低,需要长期,往往无限期的治疗.
研究的目的:
- 审查B型肝炎的历史背景.
- 评估当前的NA治疗和慢性HBV的戒断策略的现状.
- 探索未来的治疗途径,包括组合疗法,以实现功能治疗.
主要方法:
- 综合性的文献综述.
- 对HBV流行病学和治疗的历史数据的分析.
- 对新型治疗方法的当前临床试验数据的评估.
主要成果:
- 核类同类 (NA) 在控制HBV复制和改善临床结果方面表现出显著的有效性.
- 目前的NA治疗与实现HBV表面抗原血清清除的可能性低,导致无限期治疗需求.
- 结合不同药物机制的新兴治疗策略在正在进行的临床试验中显示出有希望的结果.
结论:
- 尽管在NA治疗方面取得了进展,但对慢性乙型肝炎的功能治疗仍然是一个未满足的需求.
- 针对病毒和宿主因素的新疗法对于推进HBV治疗至关重要.
- 未来的研究应该专注于组合疗法,以提高实现功能治愈和改善患者治疗结果的可能性.
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