宫健康在全身性红斑性狼中
J Patricia Dhar1,2, Heather Walline3, Gil Mor4,5,6,7
1Department of Internal Medicine/Rheumatology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Women's health reports (New Rochelle, N.Y.)
|July 21, 2023
概括
患有狼的非裔美国女性患人乳头瘤病毒 (HPV) 和子宫瘤的比例很高. 这项研究发现,他们缺乏关于HPV风险和预防的知识,突出了针对性宫健康教育和干预措施的需要.
科学领域:
- 免疫学 免疫学 免疫学
- 妇科 妇科 妇科 妇科
- 公共卫生 公共卫生
背景情况:
- 患有全身性红斑狼 (SLE) 的非裔美国人 (AA) 妇女经历了健康差异,患人乳头瘤病毒 (HPV) 感染和宫瘤的患病率增加.
- 宫癌查和HPV预防对于这种高风险人群至关重要.
研究的目的:
- 为了评估细胞学,HPV感染和阴道细胞因子生产在AA妇女与SLE使用自取样刷.
- 为了评估宫健康知识和HPV感染的风险因素在这个队列.
主要方法:
- 30名患有SLE的AA妇女 (18-50岁) 通过细胞学,HPV DNA/RNA和阴道细胞因子RNA分析进行自我采样提供了宫细胞.
- 通过记录审查,采访和调查收集了临床数据和宫病史,包括HPV知识和自我采样满意度.
主要成果:
- 队列 (平均年龄36.9) 接受免疫抑制药物的中度/重度SLE,其中63%有异常巴氏涂片史.
- 患HPV的高风险因素普遍存在:83.3%未接种HPV疫苗,73.3%不使用避孕套,9.5±7个性伴侣,26.7%吸烟.
- 13.3%的细胞系异常,70%的HPV检测结果为DNA阳性 (通常多种类型),所有的人都显示出活跃的HPV感染 (+RNA) 与多种类型的细胞因子表达.
结论:
- 在这项研究中,患有SLE的AA妇女在有关HPV相关疾病和风险降低策略的知识方面表现出重大差距.
- 这些发现强调,迫切需要加强宫健康教育,加强监测和针对这一脆弱人群的有针对性的干预措施.
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