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Vessel-sparing Excision and Primary Anastomosis
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与尿道支架相关的症状和药物治疗:简要叙述性回顾
Themistoklis Ch Bellos1, Stamatios N Katsimperis1, Sotirios G Kapsalos-Dedes1
1Department of Urology, Sismanoglio General Hospital of Athens, Athens, Greece.
Journal of clinical pharmacology
|July 21, 2023
概括
阿尔法阻断剂有效治疗尿道支架症状 (SRS),改善患者的生活质量. 对其他药物疗法和组合疗法的证据仍然相互矛盾,需要进一步研究.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
背景情况:
- 尿道支架是常用的医疗器械.
- 插入支架可能会导致令人烦的下泌尿道症状 (LUTS).
- 药物治疗正在探索管理这些支架相关症状 (SRS).
研究的目的:
- 审查各种药物治疗对尿路支架插入后患者生活质量的影响.
- 综合当前关于药物疗效管理支架相关症状 (SRS) 的证据.
主要方法:
- 进行了Medline/PubMed的非系统文献综述.
- 搜索词包括"尿路支架"",下泌尿道症状" (LUTS) 和"药物治疗".
- 包括从1987年到2023年1月的人类和英语语言的研究.
主要成果:
- 阿尔法阻断剂,特别是阿尔福佐辛,对尿路SRS具有明显的益处,这是欧洲泌尿病学协会指导方针所建议的.
- 抗胆固醇药物和mirabegron在刺激性膀症状方面显示出有效性.
- 结合疗法的证据是矛盾的;一些研究显示没有优越性比单一疗法,而另一些表明好处.
结论:
- 建议使用α抑制剂来缓解尿道支架症状 (SRS).
- 对于其他药物治疗和组合治疗,存在相互矛盾的证据.
- 需要高质量的随机试验来澄清SRS.新方法的有效性.
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