双交叉连接的磁性水凝与附甲状腺激素的编程释放促进骨愈合
Jingjunjiao Long1,2, Yitian Wang1,2, Minxun Lu1,2
1Orthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, Sichuan 610041, China.
ACS applied materials & interfaces
|July 21, 2023
概括
这项研究引入了一种磁化水凝,用于控制副甲状腺激素 (PTH) 释放,增强骨再生. 磁刺激和编程的PTH输送可以在没有每日注射的情况下加速骨愈合.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 纳米技术 纳米技术
背景情况:
- 间歇性副甲状腺激素 (PTH) 输送促进骨再生,但需要每天注射,限制临床使用.
- 磁刺激可以影响细胞命运和骨质生成.
- 开发用于控制PTH释放的新型输送系统对于骨再生疗法至关重要.
研究的目的:
- 开发一种磁化水凝,用于编程PTH释放和磁性启动,以增强骨质性承诺.
- 在磁刺激下研究PTH从水凝中的释放动力学.
- 评估磁化水凝对骨再生的体外和体内疗效.
主要方法:
- 一种GelMA-PVA (GP) 双相储水凝的配方,其中包括磁纳米粒子 (GPM) 和PTH (GPMP).
- 水凝宏观和微观性能的表征.
- 在磁刺激下PTH释放配置的体外评估和评估与MC3T3-E1前骨质细胞的细胞相容性.
- 在未接受治疗的对照组和接受GPM/GPMP治疗的组中对骨再生的体内评估.
主要成果:
- 磁化水凝展示了可编程的PTH释放,具有由磁化触发的脉动性配置,并在一个月内持续释放.
- 交替磁场刺激导致增强的累积PTH释放.
- 试验室研究显示了水凝的生物相容性和PTH促进的骨质前细胞增殖.
- 在体内研究显示,GPM和GPMP组的新骨再生,骨体积和骨矿物质密度显著增强.
结论:
- 开发的磁化水凝 (GPMP) 可实现编程PTH释放和磁性刺激,以增强骨再生.
- 该系统为治疗延迟/非结合性骨疾病提供了每日注射的有希望的替代方案.
- 控制药物输送和磁性启动的组合有效地加速骨愈合.
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