在食道癌中化学放射治疗后推迟的外科干预: (DICE) 研究
Swathikan Chidambaram1, Richard Owen2,3, Bruno Sgromo2
1Academic Surgical Unit, Department of Surgery and Cancer, Imperial College London, St Mary's Hospital, London, UK.
在食道癌的化疗放射治疗 (CRT) 后推迟手术增加了90天的死亡率,并减少了长期生存率. 在CRT后进行食道切除术的最佳时机对于更好的患者结果至关重要.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 化学辐射疗法 (CRT) 是局部晚期食道癌的标准治疗方法.
- 在CRT后的手术时间可能会影响治疗成功和患者康复.
研究的目的:
- 评估CRT后延迟手术干预对食道癌患者的生存率的影响.
主要方法:
- 一项国际性的多中心队列研究包括2867名接受食道切除术后CRT (2010-2020) 的患者.
- 根据CRT和手术之间的间隔 (0-50,51-100,101-200,>200天) 将患者分组为组.
- 评估的结果包括90天死亡率和使用多变量回归分析的5年总生存率.
主要成果:
- 延长CRT后的间隔与90天死亡率高于0-50天组相比.
- 具体来说,51-100,101-200和>200天的间隔显示死亡率的危险比率增加.
- 同样,较长的间隔与较差的5年整体存活率有关,在101-200和>200天组中具有显著的危险比率.
结论:
- 在CRT后的延迟食管切除与短期死亡率增加和长期存活率降低有关.
- 需要进一步的研究来阐明这些与长时间的手术间隔相关的不良结果背后的机制.
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