一种基于本体学的方法来改善老年患者的药物适用性:算法开发和验证研究
Elena Calvo-Cidoncha1, Julián Verdinelli2, Javier González-Bueno3
1Pharmacy Service, Hospital Clínic of Barcelona, Barcelona, Spain.
JMIR medical informatics
|July 21, 2023
概括
这项研究介绍了OntoPharma,一种基于本体学的临床决策支持系统 (CDSS),旨在提高多种疾病的老年人药物适宜性,减少不良药物事件.
科学领域:
- 医疗信息学 医疗信息学
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
背景情况:
- 在患有多种疾病的老年人中,不适当的药物使用增加了不良药物事件 (ADE) 的风险.
- 临床决策支持系统 (CDSS) 旨在提高药物适当性.
- 基于本体学的CDSS为增强药物管理提供了传统关系数据库的替代方案.
研究的目的:
- 为改善老年人药物适当性的慢性患者领域建模.
- 为这个领域在医院环境中实施和评估基于本体学的CDSSOntoPharma.
主要方法:
- 定义的领域范围,重点关注药物治疗方案的复杂性,抗胆固醇/镇静剂药物负担和不良事件触发因素.
- 使用Protégé-OWL进行本体模型建模和SPARQL进行查询.
- 在医院环境中实施OntoPharma并分析生成的警报.
主要成果:
- 为慢性病患者领域开发了6个新类和5个新属性.
- 产生了107名患者的364个警报,其中154名 (42.3%) 被接受.
- 由药物治疗方案复杂性指数 (≥40),药物负担指数 (≥1) 或异常的实验室值触发的警报.
结论:
- 使用OntoPharma的基于本体学的方法有效地支持老年人多病症的药物适当性.
- 该系统具有可扩展性,可持续性和可重复使用性,整合了临床实践.
- 在OntoPharma解决药物治疗方案的复杂性,药物负担和不良事件触发因素.
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