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血清维生素D作为患儿急性淋巴细胞白血病的危险因素的潜在作用
Pardis Nematollahi1, Sina Arabi2, Marjan Mansourian3
1Department of Pathology, School of medicine, Isfahan university of medical sciences, Isfahan, Iran.
Pediatric hematology and oncology
|July 21, 2023
概括
患有急性淋巴细胞白血病 (ALL) 的儿童比健康儿童有更高的维生素D缺乏/不足 (VDD,VDI) 率. 较低的维生素D水平与儿科ALL患者复发风险增加有关.
科学领域:
- 儿科瘤学 儿科瘤学
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
背景情况:
- 维生素D缺乏/不足 (VDD,VDI) 在儿童中很普遍.
- 关于VDD/VDI与儿科人口中的血液恶性瘤之间的关联存在有限的数据.
- 急性淋巴细胞白血病 (ALL) 是最常见的儿童癌症.
研究的目的:
- 为了比较被诊断患有ALL的儿童的血清维生素D水平与健康对照.
- 为了研究维生素D水平与儿科ALL患者复发之间的关系.
- 评估维生素D水平作为ALL儿童无复发生存 (RFS) 的预后因素.
主要方法:
- 一个病例控制研究,涉及新诊断ALL的儿童和健康的对照.
- 数据收集包括人口统计,饮食习惯和血清25(OH) D3水平.
- 在36个月内对ALL队列进行随访,以评估RFS.
主要成果:
- 在ALL病例 (28.05 ± 18.87 ng/mL) 和对照病例 (28.76 ± 12.99 ng/mL) 之间,平均血清25(OH) D3水平没有显著差异.
- 与对照组 (15.4%) 相比,ALL组的VDD/VDI患病率显著增加 (4.2%) (p < .001).与对照组相比,ALL组的VDD/VDI患病率显著增加 (15.4%).
- 维生素D水平≥20ng/mL的患者表现出更长的RFS (p = .044),这表明潜在的预防复发的保护作用.
结论:
- 与健康的同行相比,患有ALL的儿童患有VDD/VDI的患病率更高.
- 较低的维生素D水平与儿科ALL复发风险的增加有关.
- 维生素D状态可以作为在接受ALL治疗的儿童中无复发生存的预后指标.
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