寻找更好的治疗策略曼森氏菌病:一个专家的观点
Marcelo U Ferreira1,2, James Lee Crainey3, Federico G Gobbi4,5
1Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Expert opinion on pharmacotherapy
|July 21, 2023
概括
曼索内拉感染影响全球数百万人. 目前的治疗方法针对微细菌,但像抗生素这样的新方法显示出消除成年虫的希望,即使是在无症状的情况下.
科学领域:
- 寄生虫学的寄生虫学
- 热带医学 热带医学
- 传染性疾病 传染性疾病
背景情况:
- 四种曼索内拉菌在非洲和美洲感染了数百万人.
- 虽然常常无症状,但曼森氏菌病会引起各种不同的临床症状.
研究的目的:
- 审查目前针对曼松氏菌感染的治疗策略.
- 为了强调需要治疗所有曼索内拉感染,无论症状如何.
主要方法:
- 在PubMed和SciELO数据库的文献搜索到2023年5月.
- 对治疗曼索内利亚症的甲虫和抗生素治疗研究的分析.
主要成果:
- 抗虫药物 (ivermectin,mebendazole,diethylcarbamazine) 对微虫有很大的作用,它们对微虫有很大的作用.
- 针对Wolbachia内共生体的抗生素,如多西环素,可能会杀死成年虫,但目前的疗法很长.
- 新的甲虫药和较短的抗生素疗程显示出潜在的作用.
结论:
- 所有人类的曼索内拉感染都应该得到治疗.
- 曼索内洛症可能会导致显著的发病率,即使被认为是良性的.
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