在肺移植接受者中实施常规的Clostridioides difficile感染 (CDI) 初级预防
Mary Grace Fitzmaurice1,2, Benjamin Hohlfelder1, Pavithra Srinivas
1Department of Pharmacy, Cleveland Clinic, Cleveland, Ohio, USA.
Clinical transplantation
|July 21, 2023
概括
接受肺移植的人面临更高的Clostridioides difficile感染 (CDI) 风险. 口服万科米辛预防显示CDI发病率为9.3%,这表明需要优化预防时间以获得更好的结果.
科学领域:
- 传染性疾病 传染性疾病
- 移植医学 移植医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肺移植接受者有较高的Clostridioides difficile感染 (CDI) 的风险.
- 移植后的CDI与严重的并发症有关,包括移植失败和死亡率.
- 预防CDI的有效策略在这个脆弱人群中至关重要.
研究的目的:
- 为了评估初级Clostridioides difficile感染 (CDI) 预防的疗效和安全性,使用口服万科米进行预防.
- 在接受预防的肺移植接受者中确定CDI和抗万科胺素的Enterococcus (VRE) 感染/殖民的发病率.
- 确定优化肺移植受体中CDI预防策略的机会.
主要方法:
- 对86名接受肺移植的成年患者进行回顾性分析,这些患者接受了初级口服万科米辛用于CDI预防.
- 监测CDI发病率和移植后的结果.
- 评估抗胺素抗性肠球菌 (VRE) 感染或殖民率.
主要成果:
- 在接受预防的患者中,CDI的发病率为9.3% (8/86).
- 大多数CDI病例发生在预防完成后的中位数为25天.
- 观察到 4.7% 的万科米辛耐药性肠球菌 (VRE) 感染或殖民的发生率.
结论:
- 肺移植接受者的CDI初级口服万科米辛预防导致9.3%的感染率.
- 预防后CDI发生的时间表明保护持续时间的限制.
- 需要进一步的研究来优化CDI预防的持续时间,平衡好处与VRE发展等风险.
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