非手术性偏偏甲状腺症与骨肌肉功能障碍和限制性肺部疾病有关
Takasi Anush Babu1, Zia Hashim2, Zafar Neyaz3
1Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.
患有偏偏甲状腺症 (HP) 的患者表现出骨肌功能受损和限制性肺病 (RLD) 的更高患病率. 这些发现强调了需要对HP患者进行全面评估的需要.
科学领域:
- 内分泌学和新陈代谢学
- 肺部病理学 肺部病理学
- 神经肌肉疾病 神经肌肉疾病
背景情况:
- 在非手术性甲状腺功能低下症 (HP) 患者中缺乏对骨肌功能的系统评估.
- 呼吸道肌肉的参与和HP中限制性肺病 (RLD) 的可能性仍然没有研究.
研究的目的:
- 在被诊断患有下甲状腺症 (HP) 的患者中全面评估骨肌肉和肺功能.
主要方法:
- 一项观察性病例控制研究,涉及30名HP患者和40名健康对照.
- 用手握强度,SPPB,DXA和EMG来评估骨肌肉功能.
- 肺功能的评估是通过螺旋计,体,DLCO和腹膜超声波 (DUS) 来进行的.
主要成果:
- 与对照组相比,HP患者表现出较低的手握强度,SPPB得分和隔膜外/厚度.
- 电肌图显示23%的HP患者患有肌肉病,RLD在24%的HP队列中存在.
- 在HP患者中观察到血清和水平较低.
结论:
- 患有偏偏甲状腺症 (HP) 的患者表现出骨肌功能显著受损,即使没有明显的肌肉或肺部疾病.
- 相当一部分HP患者患有肌肉病和限制性肺病 (RLD),这凸显了HP的全身影响.
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