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迪亚利三硫化物通过ΔNp63/sonic hedgehog路径抑制胃癌干细胞的特性

Miaomiao Ge^1,2, Jianyun Zhu^2,3, Kefan Yi²

¹Department of General Surgery, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Molecular carcinogenesis

|July 21, 2023

概括

饮食中使用的二三硫化物 (DATS) 通过向 ΔNp63/Sonic hedgehog (SHH) 途径来抑制胃癌干细胞 (CSC). 这项研究揭示了DATS.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

胃癌经常在治疗后复发或转移,癌症干细胞 (CSC) 参与了这种进展.
声波刺 (SHH) 途径对胃中枢细胞维护至关重要,而p63蛋白质的作用尚不清楚.
食二三硫化物 (DATS) 显示出对胃癌的预防作用,但其向CSC的机制尚不清楚.

研究的目的:

调查 ΔNp63/SHH 途径在胃中枢细胞中的作用.
通过ΔNp63/SHH通路确定DATS对胃中枢细胞的抑制作用.

主要方法:

在胃瘤球体中 ΔNp63 表达的分析.
在ΔNp63过度表达时评估CSC属性.
对 ΔNp63 与 Gli1 促进体结合的研究.
在体外和体内评估DATS对CSC的影响.
检查SHH通路激活对DATS疗效的影响.

主要成果:

ΔNp63在胃瘤球上升调节,增强自我更新和CSC标志物水平.
ΔNp63通过与Gli1促进体结合,直接激活了SHH通路.
在体外和体内,DATS抑制了胃CSC的特性.
通过SHH通路的激活和ΔNp63的上调,抵消了DATS对CSC的抑制作用.

结论:

ΔNp63/SHH 途径在调节胃中枢细胞干的过程中起着至关重要的作用.
通过向ΔNp63/SHH通路,DATS有效地抑制了胃中枢细胞的特性.
这项研究阐明了DATS在打击胃癌复发和转移方面的一种新机制.

关键词:

癌症干细胞是癌症干细胞.迪亚利三硫化物胃癌胃癌是一种胃癌.声波刺之路声波刺之路的 ΔNp63 的值.

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