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在患有甲基胺使用障碍的患者中,C反应蛋白/白蛋白比率升高

Ali Baran Tanrıkulu¹, Hilal Kaya¹, Zekiye Çatak²

¹Psychiatry, Elazığ Mental Health and Diseases Hospital, Turkey Elazığ, Turkey.

International journal of psychiatry in clinical practice

|July 21, 2023

概括

反应性C蛋白/白蛋白比率 (CAR) 可能成为甲基胺使用障碍的有价值的炎症生物标志物. 在患者中观察到更高的CAR水平,这表明它有潜力监测治疗反应.

科学领域:

临床医学临床医学
毒理学毒理学毒理学
生物标志物生物标志物

背景情况:

甲基胺使用障碍 (MUD) 给个人,家庭和社会带来了重大挑战.
确定可靠的炎症生物标志物对于评估和监测MUD患者的炎症状况至关重要.
现有的研究缺乏对MUD中特定炎症比率的全面评估.

研究的目的:

研究中性粒细胞/淋巴细胞比率 (NLR),血小板/淋巴细胞比率 (PLR),单细胞/淋巴细胞比率 (MLR),C反应蛋白/白蛋白比率 (CAR) 和中性粒细胞/白蛋白比率 (NAR) 作为MUD中的炎症生物标志物的潜力.
为了比较MUD和健康对照个体之间的这些比率.
确定这些比率对MUD的预测值.

主要方法:

一项涉及139名住院MUD患者和139名匹配健康对照者的病例控制研究.
数据收集包括人口统计信息和实验室评估的炎症标志物.
统计分析包括独立的样本t测试,皮尔森相关性和二项逻辑回归.

主要成果:

与对照组相比,MUD组的CAR和NAR水平显著增加 (分别为p=0.016和p=0.048).
后勤回归分析发现CAR是MUD组成员的重要预测因素.
NLR,PLR和MLR在组之间没有显著差异.

结论:

汽车成为MUD的潜在和实际的炎症生物标志物.
在MUD患者中,CAR可以帮助监测炎症状况和治疗疗效.
需要进一步的研究来验证CAR在各种MUD群体中的实用性.

关键词:

生物标志物生物标志物在C-反应性蛋白/白蛋白的比率.炎症炎症是一种炎症.甲基胺使用障碍.

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