儿科家族高胆固醇血症中心血管疾病早期回声心脏图谱征兆
Hossam Ibrahim1, Hend Saad1, Osama Abdelaziz1
1Pediatric Cardiology Division, Department of Pediatrics, Faculty of Medicine, Specialized Pediatric Hospital, Kasr Al Ainy School of Medicine, Cairo University, Kasr Al Aini St, Cairo, 11562, Egypt.
European journal of pediatrics
|July 21, 2023
概括
在儿童患有家族性高胆固醇血症 (FH) 之前,表现出心血管问题的早期迹象,如腹功能障碍和大动脉硬性. 这些变化与高胆固醇水平有关.
科学领域:
- 心血管医学 心血管医学
- 儿童心脏病学 儿童心脏病学
- 遗传学 是一个遗传学.
背景情况:
- 家族性高胆固醇血症 (FH) 是一种遗传性疾病,可增加成人心血管风险.
- 在儿童中,FH对心血管的影响还未得到充分研究.
- 在儿科FH中早期发现心血管变化至关重要.
研究的目的:
- 评估同卵性FH的儿科患者的心血管影响.
- 使用先进的心声回声学 (TDI,2D-STE) 来评估心脏功能.
- 将FH儿童的心血管参数与健康对照进行比较.
主要方法:
- 病例对照研究比较了21名同卵性FH儿童和25名健康儿童.
- 进行了常规回声心脏图像,组织多普勒成像 (TDI) 和2D-Speckle-Tracking回声心脏图像 (2D-STE).
- 测量包括心室速度,左心室应变和大动脉硬度.
主要成果:
- FH患者表现出较高的缩血压,冠状动脉扩张和左心室缩.
- 在FH患者中观察到透缩功能障碍 (升高的 mitra E/E'比率).
- 在FH患者中,增加了大动脉硬度和轻度大动脉缺陷,并保留了LV缩功能.
结论:
- 儿科同卵性FH早期心血管标志物包括大动脉缺陷,冠状动脉扩张,LV扩张功能障碍和大动脉硬.
- 扩张性功能障碍在儿科FH中先前出现LV系统功能受损.
- 儿科FH的透气功能障碍与大动脉硬性和LDL水平相关.
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