在先前的先性妇女中进行绝经后激素治疗:芬兰的一项全国性队列研究
M Venetkoski1, O Ylikorkala1, J M Joensuu1
1Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
概括
患有妊娠前史的女性显示,随着时间的推移,荷尔蒙疗法 (HT) 使用趋势在变化,近年来使用率增加. 尽管如此,她们使用HT的总体持续时间仍然比没有先兆子史的女性要短.
科学领域:
- 生殖医学 生殖医学
- 心血管健康 心血管健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 孕前是一种与长期心血管风险相关的妊娠并发症.
- 激素治疗 (HT) 用于管理更年期症状,并可能影响心血管健康.
- 了解患有妊娠前史的妇女的HT利用模式对于风险管理至关重要.
研究的目的:
- 为了比较荷尔蒙疗法 (HT) 使用趋势,在有或没有先兆子史的妇女之间进行比较.
- 调查这些队列中HT发起和持续时间的时间变化.
- 探索先兆子史与长期HT坚持之间的潜在关联.
主要方法:
- 一项全国性队列研究分析了1969-1993年怀孕的数据.
- 包括怀孕前 (n=31,688) 和怀孕正常 (n=91,726) 的妇女.
- 从1994年至2019年间通过国家药品报销登记册追踪HT使用情况.
主要成果:
- 累积的HT使用在各组之间没有显著差异 (31.1%与30.6%).
- 从1994年至2006年间,HT使用率较低的孕前妇女,但从2007年至2019年间,HT使用率较高.
- 曾经患有先兆子的妇女使用HT的时间较短 (6.3年与7.1年).
结论:
- 在随访期间,激素治疗的使用模式在前妇女和对照妇女之间有所不同.
- 晚年在预结核妇女中增加的HT使用可能与不断变化的临床建议和风险意识相一致.
- 这些发现表明,先兆子史,心血管风险感知和激素治疗利用之间存在复杂的关系.
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