参考间隔协调:利用大数据分析的力量,在人口和测试平台之间得出共同的参考间隔
Mary Kathryn Bohn1,2, Dana Bailey3, Cynthia Balion4
1Department of Clinical Biochemistry, Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
Clinical chemistry
|July 21, 2023
概括
使用大数据协调实验室参考间隔 (RI) 提高了一致性. 这项研究为16种生化标志物得出了共同的RI,支持它们在临床决策中的可行性.
科学领域:
- 实验室医学 实验室医学
- 临床化学 临床化学
- 生物统计学 生物统计学
背景情况:
- 实验室参考间隔 (RIs) 存在显著差异,影响临床决策.
- 加拿大临床化学家协会 (CSCC) 的参考间隔协调工作组 (hRI-WG) 旨在建立协调的RI (hRI).
研究的目的:
- 使用大数据方法,对16种生化标志物获得常见的成年RI.
- 支持实验室测试的协调RI (hRI) 的实施.
主要方法:
- 从加拿大各地的社区实验室收集了16种生化标志物的大数据.
- 利用refineR方法获得协调RI (hRI),考虑年龄,性别和分析差异.
- 通过使用不同的仪器和样本类型,在9个实验室验证了拟议的hRI.
主要成果:
- 通过使用refineR方法,对大多数试验成功计算了协调RI (hRI).
- 导出的hRI满足了几个分析物的验证标准,包括性酸酶,白蛋白 (青色基) 和 (血清).
- 针对特定的分析品发现了挑战,需要进一步调查,因为验证失败或过度宽的hRI.
结论:
- 一种新的数据驱动方法证明了协调实验室参考间隔 (RI) 的可行性.
- 该研究强调了大数据分析在建立协调RI (hRI) 的潜力.
- 确定了协调和大数据分析的局限性,需要仔细考虑未来的应用.
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