修改的基于活动的厌食症范式减轻了青少年雌性小鼠的慢性食物限制诱发的超皮细胞增多症
Toru Kuriyama1, Yusuke Murata1, Reika Ohtani1
1Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
PloS one
|July 21, 2023
概括
一种调节食欲的细胞因子阿迪波涅丁可以作为神经性厌食症 (AN) 的生物标志物. 研究表明,小鼠模型中的阿迪波涅克丁水平发生了变化,这表明它有可能跟踪任何疾病状态.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 动物模型 动物模型
背景情况:
- 神经性厌食症 (AN) 是一种复杂的饮食障碍,具有显著的身体和心理影响.
- 目前的治疗缺乏特定的药物,因为不清楚的病原发生因.
- 脂肪组织中的细胞因子阿迪波涅丁 (Adiponectin) 调节食欲,是潜在的生物标志物候选者.
研究的目的:
- 调查阿迪波内克丁作为神经性厌食症疾病状态的特定生物标志物.
- 开发和验证一个修改后的小鼠模型来研究AN.
主要方法:
- 使用基于活动的厌食症 (ABA) 与食物限制和跑步轮接入,创建了一个修改过的厌食症神经性小鼠模型.
- 小鼠经历了急性和慢性食物限制阶段.
- 评估了跑步轮活动,雌性周期,自发的食物摄入量和血腺素水平.
主要成果:
- 在ABA小鼠模型中,在光线阶段和异常期间,跑轮活动增加,验证它为AN模型.
- 在ABA小鼠中,自发食物摄入量降低,血腺素水平减弱.
- 这些变化发生在急性和慢性食物限制阶段后.
结论:
- 血腺素水平可以作为一个有用的生物标志物来评估精神性厌食症的状态或阶段.
- 开发的ABA小鼠模型适合进一步研究AN病原和潜在的治疗方法.
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