反复服用静脉内抗血管内皮生长因子药物的对角膜神经的影响
Yuanyuan Qi1,2,3, Lin Cui1,2, Li Zhang1,2
1Department of Ophthalmology, the Third People's Hospital Affiliated to Dalian Medical University, Dalian, China.
Medicine
|July 21, 2023
概括
重复的静脉内抗血管内皮生长因子 (anti-VEGF) 注射可能会减少角膜神经的长度,特别是在糖尿病黄斑患者中. 建议在接受这些治疗的患者密切监测角膜神经.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
背景情况:
- 内抗血管内皮生长因子 (anti-VEGF) 注射是对视网膜疾病的常见治疗方法.
- 重复注射对角膜神经的潜在影响尚未完全理解.
研究的目的:
- 为了研究反复内内注射抗VEGF对角膜底底神经复合体的影响.
- 为了比较不同视网膜疾病和抗VEGF药物的角膜神经变化.
主要方法:
- 64名患有神经血管与年龄相关的黄斑变性 (AMD),糖尿病黄斑 (DME) 或视网膜静脉封闭 (RVO) 的患者接受了静脉注射阿弗利塞普特或拉尼比祖马布.
- 在注射前后分析了下基底神经的角膜共聚焦显微镜图像.
- 对神经密度和长度的变化进行了评估,并在不同组之间和随着时间的推移进行了比较.
主要成果:
- 在三次注射后,在大多数患者中,与基线相比,反复的静脉内抗VEGF注射没有显著改变角膜神经密度或长度.
- 在第三次注射后,糖尿病黄斑瘤组观察到角膜神经长度显著减少.
- 在第二次和第三次注射后,Aflibercept治疗显示角膜神经长度在统计学上显著下降,与拉尼比祖马布不同.
结论:
- 重复的静脉内抗VEGF注射可能会减少角膜神经的长度,特别是在糖尿病黄斑胀的患者中.
- 需要多次注射抗VEGF的患者,特别是糖尿病患者,应对角膜神经发生变化进行监测.
- 建议在注射后使用人工眼和局部抗炎疗法保护眼皮表面.
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