中枢神经系统硫酸盐缺乏是导致阿尔茨海默病的膀疾病的因果因素
Sijia He1, Shulan Qiu1, Meixia Pan1
1Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, Texas, USA.
Clinical and translational medicine
|July 21, 2023
概括
中枢神经系统硫酸盐 (ST) 缺乏会导致类似阿尔茨海默病的脂质变化和炎症,导致膀功能障碍. 维持ST水平可能有助于治疗AD相关的外周疾病.
科学领域:
- 神经科学是一个神经科学.
- 利皮多米克 (Lipidomics) 是一种消化剂.
- 神经退行性疾病 神经退行性疾病
背景情况:
- 阿尔茨海默病 (AD) 是一种脑部疾病,伴有外周器官功能障碍,例如膀控制丧失.
- 在阿尔茨海默氏症中,这些外周功能障碍的根本原因尚不清楚.
- 脊髓协调对于外周器官调节至关重要.
研究的目的:
- 研究阿尔茨海默病 (AD) 患者脊髓中脂质配置文件的作用.
- 探索中枢神经系统 (CNS) 硫酸盐 (ST) 缺乏和AD类病理之间的因果关系.
- 了解ST损失对脊髓功能和外周器官表型的影响.
主要方法:
- 在人类AD脊髓组织上进行了定量射击枪脂组学.
- 使用了患有中枢神经系统髓特异性ST缺乏症的小鼠模型.
- 在ST缺陷小鼠模型中分析了脂质组,转录组和外周器官表型.
主要成果:
- 亚得斯患者的脊髓显示肌脂减少,较低的ST水平与亚得斯严重程度相关.
- 在小鼠中,中枢神经系统ST缺陷反映了AD类脂质和转录组变化,包括髓脂质下降和炎症.
- 在小鼠中,ST缺陷破坏了脊髓功能,并导致尿膀扩大.
结论:
- 中枢神经系统ST缺陷是AD类脂质失调,炎症和膀疾病的因果因素.
- 维持ST水平为AD相关的外周并发症提供了潜在的治疗策略.
- 这项研究突出了脊髓脂质代谢在阿尔茨海默病的发病过程中的关键作用.
更多相关视频
08:27Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein
Published on: July 29, 2018
12.0K
11:12Assay Development for High Content Quantification of Sod1 Mutant Protein Aggregate Formation in Living Cells
Published on: October 4, 2017
7.3K
相关概念视频
Alzheimer's Disease: Overview
525
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
525
Alzheimer's Disease: Treatment
219
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
219
Sulfur Assimilation
45
Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
45
Glucose Transporters
23.1K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
23.1K
Disorders of the Urinary System
374
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
374
