免疫反应6:免疫监测较弱的早期直肠癌的特征
Gaya Spolverato1, Matteo Fassan2,3, Melania Scarpa4
1UOC Chirurgia Generale 3, Azienda Ospedale-Università Padova, Padua, Italy.
The British journal of surgery
|July 21, 2023
概括
早发性直肠癌表现出明显的免疫微环境特征,免疫细胞表达率较低,T细胞种群发生变化. 这表明年轻直肠癌患者的局部免疫监测受损.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 早发性直肠癌很少与遗传综合征有关,与结肠癌不同.
- 了解年轻直肠癌患者的免疫微环境和突变模式至关重要.
研究的目的:
- 在早期的直肠癌中分析局部免疫微环境.
- 为了研究早期发病的直肠癌的突变模式.
主要方法:
- 从帕多瓦大学医院的直肠癌系列中分析了基因突变.
- 将突变频率和免疫基因表达与癌症基因组图谱 (TCGA) 队列进行比较.
- 评估了来自IMMUNOlogical微环境的免疫细胞透到健康的直肠粘膜中,在直肠腺癌治疗1和2 (IMMUNOREACT) 系列中.
主要成果:
- 在早期和晚期的直肠癌之间,突变频率 (BRAF,KRAS,NRAS,微卫星不稳定性) 没有差异.
- 七个免疫反应基因在TCGA系列中显示出差异性突变频率;CD69,CD3和CD8β表达在早期发病的直肠癌中较低.
- 年轻患者表现出较低的CD4+T细胞率,但在直肠粘膜中T调节器透率较高 (IMMUNOREACT系列).
结论:
- 早期发病的直肠癌很少与常见的遗传综合征有关.
- 瘤微环境显示高突变频率,损害免疫监测和减少免疫编辑基因表达.
- 低CD4T细胞和高T调节剂表明在早期发病的直肠癌中免疫监测失衡.
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