图像导向质子疗法的跨支气管信托标记物放置后与固定性相关的因素:一项回顾性研究
Yusuke Yamaba1, Misuzu Yoshihara1, Osamu Takakuwa2
1Department of Respiratory Medicine, Thoracic Oncology Center, Nagoya City University West Medical Center, 1-1-1 Hirate-cho, Kita-ku, Nagoya, 462-8508, Japan.
Respiratory investigation
|July 21, 2023
概括
为了尽量减少图像引导质子疗法 (IGPT) 期间黄金信托标记器的脱落,建议进行外围插入和仔细考虑肺功能 (FEV1/FVC). 计划CT应在插入后至少5天发生.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 肺部病理学 肺部病理学
背景情况:
- 通过支气管插入的黄金信托标记物用于移动肺瘤的辐射和质子疗法.
- 标记物脱落是一个已知的问题,可能会影响治疗的准确性.
- 这项研究确定了影响图像引导质子疗法 (IGPT) 标记物脱落的因素.
研究的目的:
- 为了调查与黄金信托标记器在IGPT期间脱落相关的因素,用于肺癌.
- 确定减少标记物脱落和提高治疗准确性的策略.
主要方法:
- 在171名肺癌患者中插入的535个标记物的回顾性分析 (2013年6月至2021年10月).
- 基于插入位置,距离胸壁 (DMC) 和肺功能 (FEV1/FVC) 的评估标志物脱落.
- 从计划CT到后续CT的评估标志物中断.
主要成果:
- 在上叶插入标记物和FEV1/FVC≥70%与总标记物脱落相关.
- 计划和随访CT之间的学与DMC,FEV1/FVC≥70%和插入后4天内计划CT有关.
- 417/535标记在计划CT时得到确认,356/535在后续CT时得到确认.
结论:
- 通过外围插入和考虑肺功能 (FEV1/FVC) 来最大限度地减少标志物脱落.
- 优化计划CT时间:在标记器插入后至少安排5天.
- 这些策略可以提高IGPT信托标记的可靠性.
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