身体质量指数和药理学静脉血栓塞栓症创伤性脑损伤中的预防
Dina M Filiberto1, Saskya Byerly1, Emily K Lenart1
1Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee.
The Journal of surgical research
|July 21, 2023
概括
患有严重创伤性脑损伤 (TBI) 的患者面临更高的静脉血栓塞栓症 (VTE) 风险,体重指数 (BMI) 增加和预防延迟. 低分子量氨酸 (LMWH) 与未分离氨酸 (UH) 相比,可以更好地保护VTE和死亡率.
科学领域:
- 创伤外科 手术 创伤外科
- 神经外科 神经外科
- 关键护理医学 关键护理医学
背景情况:
- 患有严重创伤性脑损伤 (TBI) 的患者患静脉血栓栓塞并发症的风险增加.
- 以前的研究表明,低分子量肝素 (LMWH) 可能比未分离肝素 (UH) 在创伤患者的静脉瘤预防方面更具保护性.
研究的目的:
- 评估身体质量指数 (BMI) 和药理学VTE预防的类型对严重TBI患者的VTE发展的影响.
主要方法:
- 2019年美国外科医生学院创伤质量改善计划数据库的回顾性分析.
- 包括接受VTE预防的严重TBI患者,收集有关人口统计,损伤特征,BMI和预防时间的数据.
- 结果措施包括VTE,死亡率和神经外科干预.
主要成果:
- 较高的BMI (25-29.9 kg/m2和>30 kg/m2) 和延迟的VTE预防是VTE发展的独立预测因素.
- 增加的BMI也与较高的死亡风险有关.
- 与LMWH治疗患者相比,接受UH治疗的患者在VTE并发症的可能性更高,死亡率增加,无论BMI和预防时间如何.
结论:
- 升高的BMI和延迟启动静脉瘤预防与严重TBI患者的静脉瘤风险和死亡率增加有关.
- 低分子量氨酸 (LMWH) 与未分离氨酸 (UH) 相比,显示出对静脉瘤的保护作用.
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