高脂低乳糖亲肠道营养允许患者实现营养自主:一个病例报告
Andrew Adorno1, Jennifer Silinsky1, Michael Ghio1
1Department of Surgery, Tulane Medical Center, New Orleans, LA 70112, USA.
International journal of surgery case reports
|July 21, 2023
概括
亲肠道营养 (PN) 调整,包括切换到SMOFlipid和减少乳糖,在克罗恩病患者中逆转了肝功能障碍. 这使得手术成功并使PN独立.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 临床营养学 临床营养学
背景情况:
- 长时间的亲肠道营养 (PN) 可能会导致肝脏异常,原因是肠道刺激减少和特定的脂质配方等因素.
- 在PN中含高德克斯特和100%大豆油基脂质与肝功能障碍有关.
- 本案例报告详细介绍了PN修改,以管理患有复杂胃肠道问题的患者的肝功能障碍.
研究的目的:
- 要呈现一种PN诱导的肝功能障碍病例.
- 描述成功修改PN疗法以治疗肝脏异常的情况.
- 突出PN调整对患者结果和手术准备度的影响.
主要方法:
- 一名37岁的男性患有耐火性克罗恩病,短肠综合征和PN依赖性,呈现出肝功能测试的升高.
- 患者的家庭PN疗法具有高糖 (69%卡路里) 和低100%大豆油 (11%卡路里).
- 通过增加蛋白质,减少乳糖,并切换到SMOFlipid (>1 g/kg/day) 来改变PN.
主要成果:
- 在1.5个月内,性酸酶减少了62%,前专辑蛋白增加了56%,C反应蛋白减少了62%.
- 该PN疗法被调整为高SMOFlipid (>30%卡路里) 和低乳糖 (<30%卡路里).
- 这些PN修改导致慢性肝功能障碍的逆转.
结论:
- 在这个复杂的患者中,亲肠道营养修改有效地逆转了肝脏功能障碍.
- 肝脏问题的成功管理允许进行高风险的囊取出手术.
- 患者从PN中实现了完全的断奶,并保持了营养自主.
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