通过协调聚合物释放热/氧化触发的pyrazinic功能分子,具有发光监测能力的聚合物
Chao-Jun Wu1, Wen-Fen Zhang2, Xin Chen3
1Food Laboratory of Zhongyuan, Flavour Science Research Center of Zhengzhou University, Kexue Avenue 100, Zhengzhou, Henan 450001, PR China; Zhengzhou Tobacco Research Institute of CNTC, Fengyang Road, Zhengzhou, Henan 450001, PR China; College of Chemistry, Zhengzhou University, Kexue Avenue 100, Zhengzhou, Henan 450001, PR China.
Journal of colloid and interface science
|July 21, 2023
概括
这项研究引入了发光协调聚合物 (CPs) 作为挥发性pyrazine分子的新型载体. 这些CP提供由双刺激触发的受控释放,提高功能性化合物的可用性.
科学领域:
- 材料科学 材料科学 材料科学
- 超分子化学 超分子化学
- 药物输送系统 药物输送系统
背景情况:
- 挥发性活性分子需要专门的载体进行储存和持续的功能.
- 皮拉辛衍生物具有多样化的应用,包括调味剂,药品和害虫防治,但它们的挥发性带来了储存挑战.
研究的目的:
- 开发一种基于协调聚合物 (CP) 的新型载体,用于挥发性皮拉衍生物.
- 研究这些CP载体中的pyrazines的刺激反应释放机制.
- 展示CP作为双刺激介导的传递系统的潜力.
主要方法:
- 通过与铜化物协调pyrazine衍生物合成发光协调聚合物 (CPs).
- 研究热和氧化还原刺激对触发皮拉释放的反应.
- 通过CP结构分解的发光灭来监测pyrazine的释放.
- 负载效率的量化和释放动力学的分析.
主要成果:
- CP成功地储存了pyrazine衍生物,负载效率在31%至38%之间.
- 皮拉津的释放被热和氧化还原刺激通过Cu-N键的裂变有效地控制.
- 释放过程是可视追踪通过发光量下降.
- 控制释放遵循零级动力学.
结论:
- 协调聚合物可以作为挥发性活性分子的有效载体,如pyrazines.
- 临床医生表现出双刺激响应释放能力,可以精确控制分子传递.
- 这项工作为功能分子递送系统建立了一个新的范式,具有增强的可用性和受控释放.
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