由ICP-MS量化血水平的趋势:参考实验室回顾性研究
Nkemakonam C Okoye1,2, Lauren M Zuromski3, Kamisha L Johnson-Davis3,4
1Northwell Health Laboratories, Lake Success, NY, United States.
The journal of applied laboratory medicine
|July 21, 2023
概括
美国疾病控制和预防中心 (CDC) 将血参考值 (BLRV) 降至3.5μg/dL. 这项研究分析了血液中的含量,发现从2012年到2021年有所下降,为干预提供了机会.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 暴露会导致严重的健康问题,包括贫血,神经损伤,发育和生殖障碍.
- 在2021年,疾病控制和预防中心 (CDC) 对儿科患者 (1-5岁) 的血参考值 (BLRV) 从5μg/dL改为3.5μg/dL.
- 这一修订强调了监测和管理脆弱人群中暴露的必要性.
研究的目的:
- 为了进行血液度的回顾性分析.
- 为了评估血液中度超过新的3.5μg/dL参考值的频率.
- 评估随着时间的推移,暴露的趋势.
主要方法:
- 在静脉全血样本中,使用诱导合血质谱法 (ICP-MS) 分析了血液中的度.
- 在成年患者中对原 (ZPP) 度进行了追溯分析,并获得了相应的结果.
- 量化血计用于ZPP分析.
主要成果:
- 追溯数据分析显示,2012年至2021年期间,儿科和成人患者血度的下降趋势在2012年至2021年之间.
- 该研究确定了血液中ZPP的非参数95%范围 (15-43μg/dL) 和ZPP与血红的比率 (26-74μmol ZPP/mol血红).
结论:
- 血中减少的参考值 (BLRV) 为3.5μg/dL,为识别高暴露提供了关键值.
- 这种较低的BLRV使医疗保健提供者和公共卫生机构能够及时实施儿童暴露的医疗和环境干预措施.
- 持续监测和主动干预对于减轻暴露对健康的不良影响至关重要.
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